Article
Molecular analysis of the human MHC class I region in hereditary haemochromatosis. A study by pulsed-field gel electrophoresis.
Human genetics - 1 Oct 1990
Lord D K, Dunham I, Campbell R D, Bomford A, Strachan T, Cox T M
Abstract excerpt
The unknown allele that predisposes to the development of haemochromatosis in man has been localized to the HLA class I region on the short arm of chromosome 6. We have utilized pulsed-field gel electrophoresis in conjunction with probes that map within, or in the vicinity of, this region to search for structural lesions that may further define the disease locus. Using the enzyme Mlu I, fragments that associated...
Topics
- Alleles
- Bacterial Proteins
- Chromosomes, Human, Pair 6
- DNA
- DNA Probes
- Deoxyribonucleases, Type II Site-Specific
- Electrophoresis, Agar Gel
- Genes
- Genes, MHC Class I
- Hemochromatosis
- Humans