Article
Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6.
Development (Cambridge, England) - 1 Jan 1996
Grass S, Arnold H H, Braun T
Abstract excerpt
Mice carrying a targeted mutation in the gene for the myogenic factor Myf-5 fail to form major parts of the ribs, which leads to an unstable thorax and perinatal death. Here, we report that somites of Myf-5-deficient mice lack the expression of FGF-4 and FGF-6 while TGF beta-2 is expressed normally. Early sclerotomal markers, such as Pax-1 reveal no substantial reduction of sclerotome size. At E11.5 the...
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