Article
Short-chain lipopolysaccharide mutants of serogroup B Neisseria meningitidis of potential value for production of outer membrane vesicle vaccines.
Microbial pathogenesis - 1 Sept 1995
Andersen S R, Bjune G, Lyngby J, Bryn K, Jantzen E
Abstract excerpt
Four lipopolysaccharide (LPS) mutants (Mu-1 to Mu-4) were isolated after exposing Neisseria meningitidis strain 44/76 to pyocins from Pseudomonas aeruginosa. Parent strain LPS contained one major SDS-PAGE band expressing the immunotype determinants of L3, L3,7 and L3,7,9 and a minor band of higher mobility expressing the immunotype determinants of L8, L8a, L1,8,10 and L11. Each mutant LPS appeared as one SDS-PAGE...
Topics
- Antibodies, Bacterial
- Antibodies, Monoclonal
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Carbohydrate Sequence
- Humans
- Lipopolysaccharides
- Molecular Sequence Data
- Mutation
- Neisseria meningitidis