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Article

Improved OMV vaccine against Neisseria meningitidis using genetically engineered strains and a detergent-free purification process.

Vaccine - 5 Jul 2010

van de Waterbeemd Bas, Streefland Mathieu, van der Ley Peter, Zomer Bert, van Dijken Harry, Martens Dirk, Wijffels René, van der Pol Leo

Abstract excerpt

The use of detergent-extracted outer membrane vesicles (OMVs) is an established approach for development of a multivalent PorA vaccine against N. meningitidis serogroup B. Selective removal of lipopolysaccharide (LPS) decreases toxicity, but promotes aggregation and narrows the immune response. Detergent-free OMV vaccines retain all LPS, which preserves the native vesicle structure, but result in high toxicity...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20483197
DOI: 10.1016/j.vaccine.2010.04.082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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