Article
Outer membrane vesicle vaccines made from short-chain lipopolysaccharide mutants of serogroup B Neisseria meningitidis: effect of the carbohydrate chain length on the immune response.
Vaccine - 1 Aug 1997
Andersen S R, Bjune G, Høiby E A, Michaelsen T E, Aase A, Rye U, Jantzen E
Abstract excerpt
Outer membrane vesicle (OMV) vaccines were made from Neisseria meningitidis strain 44/76 and its two short-chain lipopolysaccharide (LPS) mutants, Mu-1 and Mu-4. Only the 44/76 vaccine contained LPS with the host antigen lacto-N-neotetraose. The protein composition of the vaccines was similar. Th...
Topics
- Animals
- Antibodies, Bacterial
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Blood Bactericidal Activity
- Carbohydrate Sequence
- Humans
- Lipopolysaccharides
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Neisseria meningitidis
- Serotyping