Article
Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant.
Infection and immunity - 1 Mar 2007
Williams Jeannette N, Skipp Paul J, Humphries Holly E, Christodoulides Myron, O'Connor C David, Heckels John E
Abstract excerpt
Current experimental vaccines against serogroup B Neisseria meningitidis are based on meningococcal outer membrane (OM) proteins present in outer membrane vesicles (OMV) in which toxic lipopolysaccharide is depleted by detergent extraction. Knowledge of the composition of OM and OMV is essential for developing new meningococcal vaccines based on defined antigens. In the current study, sodium dodecyl...
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