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Article

Defective assembly and intracellular transport of mutant paramyxovirus hemagglutinin-neuraminidase proteins containing altered cytoplasmic domains.

Journal of virology - 1 Aug 1990

Parks G D, Lamb R A

Abstract excerpt

The hemagglutinin-neuraminidase (HN) integral membrane protein of paramyxoviruses is expressed at the cell surface as a tetramer consisting of a pair of disulfide-linked dimers. HN has a large C-terminal ectodomain, a 19-residue uncleaved signal-anchor domain, and a 17-residue N-terminal cytoplasmic tail. Various mutant HN genes were constructed to examine the role of residues flanking the signal-anchor domain,...

Topics

Amino Acid Sequence
Animals
Cell Line
Cytoplasm
Fluorescent Antibody Technique
Genes, Viral
HN Protein
Intracellular Membranes
Microsomes
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Paramyxoviridae

Plasmids

Simian virus 40

Source

Open in PubMed Open full text

Identifiers

PMID: 2164588
DOI: 10.1128/JVI.64.8.3605-3616.1990
PMCID: PMC249653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2164588-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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