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Article

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems.

British journal of clinical pharmacology - 1 Oct 1995

Halliday R C, Jones B C, Smith D A, Kitteringham N R, Park B K

Abstract excerpt

1. We have assessed the interaction of the antimalarial halofantrine with cytochrome P450 (CYP) enzymes in vitro, with the use of microsomes from human liver and recombinant cell lines. 2. Rac-halofantrine was a potent inhibitor (IC50 = 1.06 microM, Ki = 4.3 microM) of the 1-hydroxylation of bufu...

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Share to Cloning, Molecular
Share to Cytochrome P-450 CYP2D6
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microsomes, Liver

Share to Mixed Function Oxygenases

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Source

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Identifiers

PMID: 8554939
DOI: 10.1111/j.1365-2125.1995.tb04559.x
PMCID: PMC1365156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8554939-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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