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Article

Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6.

European journal of clinical pharmacology - 1 Jan 1995

Masimirembwa C M, Hasler J A, Johansson I

Abstract excerpt

The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of 1'hydroxybufuralol at concentrations that might have clinical consequences in drug use. These drugs inhibited competitively bufuralol metabolism with Ki...

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Source

Identifiers

PMID: 7621845
DOI: 10.1007/BF00202169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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