Article
Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6.
European journal of clinical pharmacology - 1 Jan 1995
Masimirembwa C M, Hasler J A, Johansson I
Abstract excerpt
The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of 1'hydroxybufuralol at concentrations t...
Topics
- Adrenergic beta-Antagonists
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme Inhibitors
- Ethanolamines
- Humans
- Hydroxylation
- In Vitro Techniques
- Kinetics
- Microsomes, Liver
- Mixed Function Oxygenases
- Parasitic Diseases
- Phenotype