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Article

Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.

9 Jan 1996

Abstract excerpt

Due to the resurgence of tuberculosis and the emergence of multidrug-resistant strains, fluoroquinolones (FQ) are being used in selected tuberculosis patients, but FQ-resistant strains of Mycobacterium tuberculosis have rapidly begun to appear. The mechanisms involved in FQ resistance need to be elucidated if the effectiveness of this class of antibiotics is to be improved and prolonged. By using the...

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Identifiers

PMID: 8552639
DOI: 10.1073/pnas.93.1.362

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Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.PMID 8552639Read ↗

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Rifampicin and isoniazid resistance not promote fluoroquinolone resistance in Mycobacterium smegmatis.Semantic proximity Read ↗

MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognitionSemantic proximity Read ↗

Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter familySemantic proximity Read ↗

Microbial Drug Efflux Proteins of the Major Facilitator SuperfamilySemantic proximity Read ↗

Mechanisms of fluoroquinolone monoresistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Involvement of a natural transport system in the process of efflux-mediated drug resistance in Mycobacterium smegmatis.Semantic proximity Read ↗

Mycobacterium smegmatis MfpC is a GEF that regulates mfpA translationally to alter the fluoroquinolone efficacy.Semantic proximity Read ↗

Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein.Semantic proximity Read ↗

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