Article
Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates.
Journal of bacteriology - 1 Jan 1996
Balasubramanian V, Pavelka M S, Bardarov S S, Martin J, Weisbrod T R, McAdam R A, Bloom B R, Jacobs W R
Abstract excerpt
Genetic studies of Mycobacterium tuberculosis have been greatly hampered by the inability to introduce specific chromosomal mutations. Whereas the ability to perform allelic exchanges has provided a useful method of gene disruption in other organisms, in the clinically important species of mycoba...
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