Article
T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1996
Krishnan L, Guilbert L J, Wegmann T G, Belosevic M, Mosmann T R
Abstract excerpt
Maternal immune responses can influence fetal survival and several cytokines have harmful or protective effects on pregnancy. The Th1 cytokines IFN-gamma and IL-2 can cause fetal loss, whereas the Th2 cytokine IL-10 is protective. However, infections such as leishmaniasis show the opposite patter...
Topics
- Animals
- Disease Susceptibility
- Embryo Implantation
- Female
- Fetal Resorption
- Genetic Predisposition to Disease
- Interferon-gamma
- Interleukin-10
- Interleukin-2
- Leishmania major
- Leishmaniasis, Cutaneous
- Male
- Mice
- Mice, Inbred BALB C