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Article

TLR9 Inhibition Shortly After Mating Increases Fetal Resorption and Alters B- and T-Cell Costimulatory Phenotypes in an Abortion-Prone Mouse Model.

International journal of molecular sciences - 14 Jan 2026

Lorek Daria, Kedzierska Anna Ewa, Slawek Anna, Kubik Paulina, Chelmonska-Soyta Anna

Abstract excerpt

Maternal immune tolerance and controlled inflammatory responses are essential for fetal development and successful pregnancy. Regulatory T cells (Tregs) and B cells with regulatory properties (Bregs) maintain this balance by limiting excessive immune activation through the secretion of anti-inflammatory and tolerogenic cytokines, such as IL-10, TGF-β, and IL-35. Moreover, alterations in the costimulatory...

Topics

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B-Lymphocytes
Lymphocyte Activation
Mice, Inbred CBA
Mice, Inbred DBA
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Regulatory

Toll-Like Receptor 9

Source

Open in PubMed Open full text

Identifiers

PMID: 41596497
DOI: 10.3390/ijms27020848
PMCID: PMC12840859

Genes

TLR9
CD28
CD80
CD86

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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