Article
PDL1 blockage increases fetal resorption and Tfr cells but does not affect Tfh/Tfr ratio and B-cell maturation during allogeneic pregnancy.
Cell death & disease - 12 Feb 2020
Zeng Weihong, Qin Shi, Wang Renjie, Zhang Yuchen, Ma Xiaoling, Tian Fuju, Liu Xiao-Rui, Qin Xiaoli, Liao Shujie, Sun Liqun, Lin Yi
Abstract excerpt
A successful pregnancy requires sophisticated regulation of uterine microenvironment to guarantee the existence of semi-allogeneic conceptus without immune rejection. T follicular regulatory (Tfr) cells exert a suppressive effect on Tfh-cell expansion, B-cell response, and antibody production. Although accumulating evidence has demonstrated that dysregulations of Tfr cells can bring on various immunological...
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