An alternative splice variant of human IL-4, IL-4 δ 2, inhibits IL-4-stimulated T cell proliferation

Abstract excerpt

Alternative splicing of mRNA can generate protein isoforms that are preferentially expressed in different tissues or during different states of cell differentiation or activation. Protein isoforms may have different functions. In this study, we cloned, expressed, and tested functional effects of a naturally occurring splice variant of human IL-4, called IL-4 delta 2. In IL-4 delta 2, the second exon of IL-4 is...

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