Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-kappa B homologue.

doi:10.1016/0925-4773(95)00388-h

Back to search

Article

Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-kappa B homologue.

Mechanisms of development - 1 Aug 1995

Richardson J C, Gatherer D, Woodland H R

Abstract excerpt

High level over-expression of XrelA1, a homologue of the p65 sub-unit of NF-kappa B and of Drosophila dorsal, arrests Xenopus development at the gastrula stage, producing a reduction in the levels of expression of various genes of developmental interest without general reduction in transcription...

Topics

Animals
Culture Techniques
Drosophila
Embryo, Nonmammalian
Gene Expression Regulation, Developmental
Microinjections
Mutation
NF-kappa B
Reference Values
Sequence Homology, Amino Acid
Species Specificity
Transcription, Genetic
Xenopus

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.