Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue.

Development (Cambridge, England) - 1 Jan 2003

Cherbas Lucy, Hu Xiao, Zhimulev Igor, Belyaeva Elena, Cherbas Peter

Abstract excerpt

The three Drosophila EcR isoforms differ only at their N termini; thus, they share the conserved ligand-binding domain transcriptional activation function (AF2) and only differ in the unconserved A/B region, which contains a second, isoform-specific, activation function (AF1). We have developed a dominant-negative mutant EcR (EcR-DN), expressed it in flies with the GAL4/UAS system, and used it to block ecdysone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes
Share to Ecdysone
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to Photoreceptor Cells, Invertebrate

Share to Receptors, Steroid

Share to Salivary Glands

Source

Identifiers

PMID: 12466195
DOI: 10.1242/dev.00205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue.PMID 12466195Read ↗

Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila.Semantic proximity Read ↗

Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development.Semantic proximity Read ↗

Creation of EcR isoform-specific mutations in Drosophila melanogaster via local P element transposition, imprecise P element excision, and male recombination.Semantic proximity Read ↗

Dynamic expression of broad-complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis.Semantic proximity Read ↗

Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responsesSemantic proximity Read ↗

An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing discSemantic proximity Read ↗

DHR3 is required for the prepupal-pupal transition and differentiation of adult structures during Drosophila metamorphosis.Semantic proximity Read ↗

Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion.Semantic proximity Read ↗

Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans.Semantic proximity Read ↗

Alternate transcripts of the Drosophila "activator" E2F are necessary for maintenance of cell cycle exit during development.Semantic proximity Read ↗

A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila.Semantic proximity Read ↗

Drosophila hormone receptor 38 functions in metamorphosis: a role in adult cuticle formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.