Article
Detection of a 5' UTR variation in the HCV genome after a long-term in vitro infection.
Research in virology - 1 Jan 2000
Valli M B, Bertolini L, Iacovacci S, Ponzetto A, Carloni G
Abstract excerpt
The TOFE lymphoid cell line from normal human bone marrow is susceptible to infection by a hepatitis C virus (HCV) serum strain. A sequence analysis of the 5' untranslated region (UTR) of HCV before and after long-term in vitro infection revealed one base substitution at position -158 (C > T) of the 5' UTR. We performed the direct sequencing of 5' UTR polymerase chain reaction-amplified sequences of the HCV...
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