Article
Cellular oncogenes, mutations and cancer.
Anticancer research - 1 Jan 2000
Spandidos D A
Abstract excerpt
The multistep nature of cancer suggested from chemical carcinogenesis studies, epidemiological data and cell culture experiments could be explained by the occurrence of somatic mutations resulting in inappropriate expression of normal cellular sequences which have an intrinsic potential of becoming cancer genes. The discovery that cancer genes could be transferred from one cell to another lends further support...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Cricetinae
- Humans
- Lung
- Models, Genetic
- Mutation
- Neoplasms
- Oncogenes