Article
Effects of all-trans-retinoic acid on limb development in the genetic polydactyly mouse.
The Journal of toxicological sciences - 1 Sept 1995
Tamagawa M, Morita J, Naruse I
Abstract excerpt
Pdn/+ female mice, mated with Pdn/+ males, were treated with 40 mg/kg body weight of all-trans-retinoic acid (RA) intraperitoneally on day 10 or 11 of gestation, and effects on the limb development were investigated. RA treatment induced the shortening of stylopodium and zygopodium. In the presen...
Topics
- Animals
- Apoptosis
- Extremities
- Female
- Genotype
- Gestational Age
- Limb Deformities, Congenital
- Male
- Mice
- Phenotype
- Polydactyly
- Pregnancy
- Tretinoin