Rescue of the limb deformity in hammertoe mutant mice by retinoic acid-induced cell death.

Abstract excerpt

Retinoids, used therapeutically primarily in the treatment of skin disorders, are potent teratogens. Several craniofacial, neural tube, and limb defects derive from a selective increase in cell death by retinoic acid in sites of spontaneous programmed cell death. Previously we showed that programmed cell death in the limb was apoptotic, and that the webbing of the foot of the Hammertoe mutant mouse correlates...

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