Rescue of the limb deformity in hammertoe mutant mice by retinoic acid-induced cell death.

doi:10.1002/(SICI)1097-0177(199704)208:4<466::AID-AJA3>3.0.CO;2-G

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Article

Rescue of the limb deformity in hammertoe mutant mice by retinoic acid-induced cell death.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 1997

Ahuja H S, James W, Zakeri Z

Abstract excerpt

Retinoids, used therapeutically primarily in the treatment of skin disorders, are potent teratogens. Several craniofacial, neural tube, and limb defects derive from a selective increase in cell death by retinoic acid in sites of spontaneous programmed cell death. Previously we showed that program...

Topics

Animals
Apoptosis
Congenital Abnormalities
Female
Limb Deformities, Congenital
Male
Mice
Mice, Mutant Strains
Phenotype
Promoter Regions, Genetic
Receptors, Retinoic Acid
Tretinoin

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