Article
A CCG repeat polymorphism adjacent to the CAG repeat in the Huntington disease gene: implications for diagnostic accuracy and predictive testing.
Human molecular genetics - 1 Jan 1994
Andrew S E, Goldberg Y P, Theilmann J, Zeisler J, Hayden M R
Abstract excerpt
The polymorphic CAG repeat that is expanded on Huntington disease (HD) chromosomes is flanked by a CCG repeat. Here we show that this CCG tract, previously assumed to be invariant at seven CCG repeats, is also polymorphic. We have identified five CCG alleles from 205 normal chromosomes, with 137 (67%) having alleles of seven repeats, five (2%) with nine repeats, 61 (30%) with 10 repeats, one (0.5%) with 11...
Topics
- Adult
- Alleles
- Base Sequence
- DNA Primers
- Humans
- Huntington Disease
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Reference Values
- Repetitive Sequences, Nucleic Acid