Article
A single allele from the polymorphic CCG rich sequence immediately 3' to the unstable CAG trinucleotide in the IT15 cDNA shows almost complete disequilibrium with Huntington's disease chromosomes in the Scottish population.
Human molecular genetics - 1 Jan 1994
Barron L H, Rae A, Holloway S, Brock D J, Warner J P
Abstract excerpt
The CCG rich sequence immediately 3' to the CAG repeat that is expanded in Huntington's disease (HD) has recently been shown to be polymorphic with at least 4 alleles differing by multiples of 3 bp being found in the normal population. We have studied the allele distribution in 180 HD families re...
Topics
- Alleles
- Base Composition
- Base Sequence
- Chromosomes, Human
- DNA
- DNA Primers
- DNA, Complementary
- Demography
- Female
- Humans
- Huntington Disease
- Linkage Disequilibrium
- Male
- Polymerase Chain Reaction
- Polymorphism, Genetic