Article
Dynamic mutation in Dutch Huntington's disease patients: increased paternal repeat instability extending to within the normal size range.
Journal of medical genetics - 1 Dec 1993
De Rooij K E, De Koning Gans P A, Skraastad M I, Belfroid R D, Vegter-Van Der Vlis M, Roos R A, Bakker E, Van Ommen G J, Den Dunnen J T, Losekoot M
Abstract excerpt
Analysis of the distribution of normal and expanded alleles of the polymorphic (CAG)n repeat in the IT15 gene in the Dutch population confirmed the presence of an expanded repeat on all Huntington's disease (HD) chromosomes. Our results show that the size distributions of normal and affected alle...
Topics
- Adult
- Age of Onset
- Aged
- Alleles
- Child
- Fathers
- Female
- Haplotypes
- Humans
- Huntington Disease
- Male
- Middle Aged
- Mutation
- Netherlands
- Oligodeoxyribonucleotides