Article
No recurrent structural abnormalities apart from i(12p) in primary germ cell tumors of the adult testis.
Genes, chromosomes & cancer - 1 Oct 1995
van Echten J, Oosterhuis J W, Looijenga L H, van de Pol M, Wiersema J, te Meerman G J, Schaffordt Koops H, Sleijfer D T, de Jong B
Abstract excerpt
Malignant transformation may be caused by gene deregulation resulting from specific chromosomal rearrangements, by amplification, by mutations in proto-oncogenes, by loss of tumor suppressor genes, or a combination of these. We investigated the role of numerical and structural chromosomal abnormalities in 102 cytogenetically abnormal cases of primary testicular germ cell tumors of adolescents and adults (TGCT)...
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