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Article

Fluorescence In Situ Hybridization (FISH) Detection of Chromosomal 12p Anomalies in Testicular Germ Cell Tumors.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Cheng Liang, Davidson Darrell D, Montironi Rodolfo, Wang Mingsheng, Lopez-Beltran Antonio, Masterson Timothy A, Albany Costantine, Zhang Shaobo

Abstract excerpt

Gains of genetic material or internal rearrangements of chromosome 12p, including 12p overrepresentation or isochromosome 12p [i(12p)], are observed in virtually all germ cell tumors (GCT), in all histologic subtypes, and from various body locations. The chromosomal region involved in these alterations contains the growth and survival promoting oncogene KRAS (12p12.1). Gains or rearrangements of 12p characterize...

Topics

Biomarkers, Tumor
Chromosome Aberrations
Chromosomes, Human, Pair 12
Diagnosis, Differential
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Neoplasms, Germ Cell and Embryonal

Quality Control

Testicular Neoplasms

Source

Identifiers

PMID: 32852756
DOI: 10.1007/978-1-0716-0860-9_4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Fluorescence In Situ Hybridization (FISH) Detection of Chromosomal 12p Anomalies in Testicular Germ Cell Tumors.PMID 32852756Read ↗

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