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Article

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995

Wiler R, Leber R, Moore B B, VanDyk L F, Perryman L E, Meek K

Abstract excerpt

V(D)J rearrangement is the molecular mechanism by which an almost infinite array of specific immune receptors are generated. Defects in this process result in profound immunodeficiency as is the case in the C.B-17 SCID mouse or in RAG-1 (recombination-activating gene 1) or RAG-2 deficient mice. I...

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Identifiers

PMID: 8524788
DOI: 10.1073/pnas.92.25.11485
PMCID: PMC40426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8524788-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.PMID 8524788Read ↗

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Evaluation of a test for identification of Arabian horses heterozygous for the severe combined immunodeficiency trait.Semantic proximity Read ↗

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