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Article

[A new hereditary cause of portal vein thrombosis: the abnormal resistance to activated protein C by the Arg 506-->Gln mutation of the gene of factor V].

Gastroenterologie clinique et biologique - 1 Jan 2000

Levoir D, Aubertin J M, Alhenc-Gelas M, Bloch F, Becheur H, Petite J P

Abstract excerpt

We report 2 cases of portal vein thrombosis associated with a single point mutation in the factor V gene that replaces arginine in residue 506 with glutamine. This mutation induces abnormal resistance to anticoagulant activity of activated protein C and increases the risk of deep vein thrombosis. Both patients had a personal and familial history of deep vein thrombosis. Intraabdominal neoplasia or infection,...

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PMID: 8522125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[A new hereditary cause of portal vein thrombosis: the abnormal resistance to activated protein C by the Arg 506-->Gln mutation of the gene of factor V].PMID 8522125Read ↗

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Resistance to activated protein C caused by a factor V gene mutation.Semantic proximity Read ↗

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Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Resistance to activated protein C due to factor V R506Q mutation as a cause of venous thrombosis.Semantic proximity Read ↗

[Activated protein C resistance and factor V Leiden: clinical interest].Semantic proximity Read ↗

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Predisposition to thrombosis by a factor V mutation causing hereditary resistance to activated protein C.Semantic proximity Read ↗

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