Article
Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.
Circulation - 15 Dec 1995
Schwartz P J, Priori S G, Locati E H, Napolitano C, Cantù F, Towbin J A, Keating M T, Hammoude H, Brown A M, Chen L S, Colatsky T J
Abstract excerpt
BACKGROUND: The genes for the long QT syndrome (LQTS) linked to chromosomes 3 (LQT3) and 7 (LQT2) were identified as SCN5A, the cardiac Na+ channel gene, and as HERG, a K+ channel gene. These findings opened the possibility of attempting gene-specific control of ventricular repolarization. We tested the hypothesis that the QT interval would shorten more in LQT3 than in LQT2 patients in response to mexiletine and...
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