Article
Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.
Circulation - 2 Jan 2001
Schwartz P J, Priori S G, Spazzolini C, Moss A J, Vincent G M, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating M T, Towbin J A, Beggs A H, Brink P, Wilde A A, Toivonen L, Zareba W, Robinson J L, Timothy K W, Corfield V, Wattanasirichaigoon D, Corbett C, Haverkamp W, Schulze-Bahr E, Lehmann M H, Schwartz K, Coumel P, Bloise R
Abstract excerpt
BACKGROUND: The congenital long-QT syndrome (LQTS) is caused by mutations on several genes, all of which encode cardiac ion channels. The progressive understanding of the electrophysiological consequences of these mutations opens unforeseen possibilities for genotype-phenotype correlation studies. Preliminary observations suggested that the conditions ("triggers") associated with cardiac events may in large part...
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