Clinical isolates of HIV-1 contain few pre-existing proteinase inhibitor resistance-conferring mutations.

doi:10.1016/0167-4838(95)00167-1

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Article

Clinical isolates of HIV-1 contain few pre-existing proteinase inhibitor resistance-conferring mutations.

Biochimica et biophysica acta - 6 Dec 1995

Yamaguchi K, Byrn R A

Abstract excerpt

Proteinase inhibitors are an important new class of antiviral agents for AIDS, however, in vitro experiments have identified proteinase mutations that confer resistance to several different families of the inhibitors. This study was undertaken to determine if these resistance-conferring amino-aci...

Topics

Amino Acid Sequence
Base Sequence
Drug Resistance, Microbial
HIV Protease
HIV Protease Inhibitors
HIV Seropositivity
HIV-1
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA
Sequence Homology, Amino Acid

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