Article
Expression, purification and characterization of multigram amounts of a recombinant hybrid HV1-HV2 hirudin variant expressed in Saccharomyces cerevisiae.
Protein expression and purification - 1 Jun 1993
Lehman E D, Joyce J G, Bailey F J, Markus H Z, Schultz L D, Dunwiddie C T, Jacobson M A, Miller W J
Abstract excerpt
Hirudin (HIR), derived from leeches, and tick anticoagulant peptide (TAP) are polypeptide protease inhibitors of thrombin and coagulation factor Xa (fXa), respectively, and they have both shown utility in vitro and in vivo as potent antithrombotic agents. A thorough side-by-side comparison of the in vivo efficacy of factor Xa inhibition compared to thrombin inhibition by TAP and HIR, respectively, required...
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