Article
Lack of association between schizophrenia and alleles in the dopamine D3 receptor gene.
Acta psychiatrica Scandinavica - 1 May 1993
Jönsson E, Lannfelt L, Sokoloff P, Schwartz J C, Sedvall G
Abstract excerpt
Dopamine receptor dysfunction has been implicated in the pathophysiology of schizophrenia. Schizophrenic patients (n = 76) and control subjects (n = 53) were examined for allele frequencies in a 2-allele BalI polymorphism, causing a serine-->glycine amino acid substitution in the coding sequence...
Topics
- Adult
- Aged
- Alleles
- Base Sequence
- Female
- Genome
- Homozygote
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Polymorphism, Genetic
- Psychiatric Status Rating Scales