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Article

A comparative study of the genetic diversity of the 42kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2007

Pacheco M Andreina, Poe Amanda C, Collins William E, Lal Altaf A, Tanabe Kazuyuki, Kariuki Simon K, Udhayakumar Venkatachalam, Escalante Ananias A

Abstract excerpt

We investigated the genetic diversity of the 42kDa fragment of the merozoite surface protein 1 (MSP-1) antigen in Plasmodium falciparum and P. vivax, as well as in non-human primate malarial parasites. This fragment undergoes a proteolytic cleavage generating two fragments of 19kDa (MSP-1(19)) and 33kDa (MSP-1(33)) that are critical in erythrocyte invasion. We found that overall the MSP-1(33) fragment exhibits...

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Identifiers

PMID: 17010678
DOI: 10.1016/j.meegid.2006.08.002
PMCID: PMC1853303

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