Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy.

Cardiovascular research - 1 Oct 1999

Redwood C S, Moolman-Smook J C, Watkins H

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is one of the most frequently occurring inherited cardiac disorders, affecting up to 1 in 500 of the population. Molecular genetic analysis has shown that HCM is a disease of the sarcomere, caused by mutations in certain contractile protein genes. To date seven disease-associated genes have been identified, those encoding beta-myosin heavy chain, both regulatory and essential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Hypertrophic
Share to Contractile Proteins
Share to Myosin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myosin Light Chains

Share to Sarcomeres

Share to Tropomyosin

Share to Troponin I

Share to Troponin T

Source

Identifiers

PMID: 10615387
DOI: 10.1016/s0008-6363(99)00213-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy.PMID 10615387Read ↗

Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes.Semantic proximity Read ↗

Contractile protein mutations and heart disease.Semantic proximity Read ↗

The molecular genetic basis for hypertrophic cardiomyopathy.Semantic proximity Read ↗

Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history.Semantic proximity Read ↗

Molecular and Cellular Aspects of Troponin CardiomyopathiesSemantic proximity Read ↗

Hypertrophic cardiomyopathy: pathological features and molecular pathogenesis.Semantic proximity Read ↗

Genetic basis of hypertrophic cardiomyopathy: from bench to the clinics.Semantic proximity Read ↗

Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeSemantic proximity Read ↗

Hypertrophic cardiomyopathy: from gene defect to clinical disease.Semantic proximity Read ↗

Molecular genetics of hypertrophic cardiomyopathy.Semantic proximity Read ↗

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.Semantic proximity Read ↗

Phenotypic variation and targeted therapy of hypertrophic cardiomyopathy using genetic animal models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.