Activation of mutant forms of DnaA protein of Escherichia coli by DnaK and GrpE proteins occurs prior to DNA replication.

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Article

Activation of mutant forms of DnaA protein of Escherichia coli by DnaK and GrpE proteins occurs prior to DNA replication.

The Journal of biological chemistry - 25 Jun 1993

Hupp T R, Kaguni J M

Abstract excerpt

Mutant forms of DnaA protein, inert in a replication system composed of other purified proteins, are "activated" by DnaK and GrpE heat shock proteins (Hupp, T. R., and Kaguni, J. M. (1993) J. Biol. Chem. 268, 13137-13142). The effect of these heat shock proteins on DnaA5 and DnaA46 protein was se...

Topics

Adenosine Triphosphate
Antibodies, Monoclonal
Bacterial Proteins
DNA Replication
DNA, Bacterial
DNA-Binding Proteins
Escherichia coli
Escherichia coli Proteins
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Hot Temperature
Hydrolysis
Mutation

Source

Open in PubMed

Identifiers

PMID: 8514753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8514753-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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