Article
Novel heat shock protein HspQ stimulates the degradation of mutant DnaA protein in Escherichia coli.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2004
Shimuta Toh-ru, Nakano Kiyotaka, Yamaguchi Yoko, Ozaki Shogo, Fujimitsu Kazuyuki, Matsunaga Chika, Noguchi Kenji, Emoto Akiko, Katayama Tsutomu
Abstract excerpt
Escherichia coli DnaA protein initiates chromosomal replication and is an important regulatory target during the replication cycle. In this study, a suppressor mutation isolated by transposon mutagenesis was found to allow growth of the temperature-sensitive dnaA508 and dnaA167 mutants at 40 degrees C. The suppressor consists of a transposon insertion in a previously annotated ORF, here termed hspQ, a novel heat...
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