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Article

Missense mutations in the Bacillus subtilis gnt repressor that diminish operator binding ability.

Journal of molecular biology - 20 May 1993

Yoshida K, Fujita Y, Sarai A

Abstract excerpt

The Bacillus subtilis gnt operon is negatively regulated by the gnt repressor (GntR, 243 amino acids), which is antagonized by gluconate. The GntR protein belongs to a new family of bacterial regulatory proteins (GntR family). To locate the DNA-binding domain of the GntR protein, we obtained mutations of this protein, by hydroxylamine mutagenesis, which diminish its operator binding ability. Sequence analysis of...

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Identifiers

PMID: 8510140
DOI: 10.1006/jmbi.1993.1270

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