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MDM2 in Tumor Biology and Cancer Therapy: A Review of Current Clinical Trials

2025-10-09

Abstract excerpt

The Murine Double Minute 2 (MDM2) gene encodes an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53, maintaining low p53 levels through ubiquitination and proteasomal degradation. MDM2 overexpression in various malignancies leads to reduced p53 activity, contributing to tumor initiation and resistance to therapies. As such, MDM2 is a promising target for drug development. Innovative small-mole...

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Literature Corpus work
ba11b546-c29d-5b5c-ba6a-f7763a3a14fb
DOI
10.20944/preprints202510.0664.v1
Open publication

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MDM2 in Tumor Biology and Cancer Therapy: A Review of Current Clinical TrialsDOI 10.20944/preprints202510.0664.v1
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