Article
Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.
The EMBO journal - 1 May 1993
Flint A J, Gebbink M F, Franza B R, Hill D E, Tonks N K
Abstract excerpt
The non-transmembrane protein tyrosine phosphatase, PTP1B, comprises 435 amino acids, of which the C-terminal 114 residues have been implicated in controlling both localization and function of this enzyme. Inspection of the sequence of the C-terminal segment reveals a number of potential sites of...
Topics
- Alanine
- Amino Acid Sequence
- CDC2 Protein Kinase
- Cell Cycle
- Electrophoresis, Polyacrylamide Gel
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinase C
- Protein Tyrosine Phosphatases
- Serine
- Tetradecanoylphorbol Acetate