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Article

Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis : analysis of enzymatic domains in four polyketide synthases

1 Sept 2001

Abstract excerpt

The analysis of the incorporation of 13C-labeled precursors into avermectins indicates that the avermectin aglycons are synthesized by head-to-tail condensation of various acyl groups, which is similar to the biosynthesis of other polyketides. Polyketide synthases (PKS) use the appropriate CoA ester as a primer and add acetate units from malonyl-CoA and propionate units from methylmalonyl-CoA to assemble the...

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PMID: 11780788
DOI: 10.1038/sj.jim.7000092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis : analysis of enzymatic domains in four polyketide synthasesPMID 11780788Read ↗

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