Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The biology of normal and neoplastic stem cells in CML.

Leukemia & lymphoma - 1 Jan 1993

Eaves C, Udomsakdi C, Cashman J, Barnett M, Eaves A

Abstract excerpt

Chronic myeloid leukemia (CML) has long served as a prototype malignancy for basic as well as clinical studies aimed at developing curative cancer treatment protocols. Well established features of chronic phase CML are its origin in a pluripotent stem cell, a now well defined molecular genetic basis involving the creation of a BCR-ABL fusion gene and evidence of resultant abnormalities in the mechanisms that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Cell Differentiation
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clone Cells

Share to Cytokines

Share to Hematopoietic Stem Cells

Share to Phenotype

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8251904
DOI: 10.3109/10428199309047894

Genes

BCR
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The biology of normal and neoplastic stem cells in CML.PMID 8251904Read ↗

Chronic Myeloid Leukemia Stem CellsSemantic proximity Read ↗

Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia.Semantic proximity Read ↗

Insights into the stem cells of chronic myeloid leukemia.Semantic proximity Read ↗

Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemiaSemantic proximity Read ↗

Chronic Myeloid Leukemia Stem CellsSemantic proximity Read ↗

Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level.Semantic proximity Read ↗

The CML stem cell: Evolution of the progenitorSemantic proximity Read ↗

Chronic Myeloid Leukemia Stem Cell BiologySemantic proximity Read ↗

The chronic myeloid leukemia stem cell: stemming the tide of persistenceSemantic proximity Read ↗

Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia.Semantic proximity Read ↗

Characterization of a hierarchy in human acute myeloid leukemia progenitor cellsSemantic proximity Read ↗

Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia: Is It Worth the Effort?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.