Article
HLA-DPB1 allele associates with early-onset myasthenia gravis in Japan.
Neurology - 1 Apr 1993
Horiki T, Moriuchi J, Inoko H, Morita K, Tsuji K, Shinohara Y, Ichikawa Y, Arimori S
Abstract excerpt
We investigated the HLA-DPB1 allele in 43 unrelated Japanese patients with myasthenia gravis (MG) using digestion of polymerase chain reaction (PCR)-amplified DNA with allele-specific restriction endonucleases (PCR-RFLP method). We found a higher frequency of the DPB1*0201 allele in female patients whose ages at onset were less than 30 years (83.3%) than in controls (35.6%). The study also included serologic...
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