Article
A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan.
Clinical immunology (Orlando, Fla.) - 1 Feb 2004
Shinomiya Noriaki, Nomura Yoshiko, Segawa Masaya
Abstract excerpt
To investigate the correlation between clinical features and HLA DR/DQ genetic variability in myasthenia gravis (MG), we evaluated HLA DR/DQ allele frequencies in 87 Japanese patients with childhood-onset disease. HLA genotypes DRB1*1302/DQA1*0102/DQB1*0604 and DRB1*0901/DQA1*0301/DQB1*0303 were significantly higher in patients than in healthy controls (P(c) < 0.0001, RR = 5.5; P(c) < 0.0001, RR = 8.5, for two...
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