Combinations of HLA-DPB1 and HLA-DQB1 alleles determine susceptibility to early-onset myasthenia gravis in Japan.

doi:10.3109/08916939409008008

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Article

Combinations of HLA-DPB1 and HLA-DQB1 alleles determine susceptibility to early-onset myasthenia gravis in Japan.

Autoimmunity - 1 Jan 1994

Horiki T, Inoko H, Moriuchi J, Ichikawa Y, Arimori S

Abstract excerpt

HLA class II alleles in the DQA1, DQB1, DRB1, and DPB1 genes were investigated in Japanese patients with myasthenia gravis (MG) by digestion of polymerase chain reaction amplified DNAs with allele specific restriction endonucleases (PCR-RFLP). A significantly higher frequency of DQB1*03, which includes *0301, *0302, *0303 and determines the serological DQ3 specificity, was observed in female patients less than 30...

Topics

Adolescent
Adult
Age of Onset
Alleles
Amino Acid Sequence
Asian People
Case-Control Studies
Child
Child, Preschool
Disease Susceptibility
Female
Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

HLA-DP Antigens

HLA-DP beta-Chains

HLA-DQ Antigens

HLA-DQ alpha-Chains

HLA-DQ beta-Chains

Source

Open in PubMed

Identifiers

PMID: 7749041
DOI: 10.3109/08916939409008008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7749041-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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