HLA class II antigens and DNA restriction fragment length polymorphism in myasthenia gravis in Japan.

Abstract excerpt

Human leukocyte phenotypes and genes in the HLA class II regions were studied in 46 Japanese patients with myasthenia gravis. When the HLA phenotypes of the patients with myasthenia gravis were compared with the controls, an increased frequency of HLA-DRw53 was observed in females less than 30 years of age. The genomic DNAs of the HLA-DRw53-positive patients and DRw53-positive controls were analyzed by using four...

Topics

• Adolescent
• Adult
• Age Factors
• Child
• Child, Preschool
• DNA Probes, HLA
• Female
• HLA-D Antigens
• HLA-DR Antigens
• HLA-DRB4 Chains
• Humans
• Japan