Article
Molecular mechanism of transcription-repair coupling.
Science (New York, N.Y.) - 2 Apr 1993
Selby C P, Sancar A
Abstract excerpt
Lesions in the transcribed strand block transcription and are repaired more rapidly than lesions in the nontranscribed (coding) strand which do not block RNA polymerase (RNAP). It has been shown previously that in Escherichia coli the mfd (mutation frequency decline) gene is necessary for strand-specific repair. The mfd gene was cloned and sequenced and the Mfd protein was purified and used to reconstitute...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Binding Sites
- Cloning, Molecular
- DNA Helicases
- DNA Repair
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Endodeoxyribonucleases
- Escherichia coli
- Escherichia coli Proteins