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Article

Structure and function of transcription-repair coupling factor. I. Structural domains and binding properties.

The Journal of biological chemistry - 3 Mar 1995

Selby C P, Sancar A

Abstract excerpt

The 130-kDa mfd gene product is required for coupling transcription to repair in Escherichia coli. Mfd displaces E. coli RNA polymerase (Pol) stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription. Here, the interactions of Mfd (transcription-repair coupling factor, TRCF) with DNA, RNA Pol, and UvrA were investigated. TRCF bound...

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Identifiers

PMID: 7876261
DOI: 10.1074/jbc.270.9.4882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure and function of transcription-repair coupling factor. I. Structural domains and binding properties.PMID 7876261Read ↗

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The sequence and structure of the Mfd protein dictate its role during virulenceSemantic proximity Read ↗

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