Article
Structure and function of transcription-repair coupling factor. I. Structural domains and binding properties.
The Journal of biological chemistry - 3 Mar 1995
Selby C P, Sancar A
Abstract excerpt
The 130-kDa mfd gene product is required for coupling transcription to repair in Escherichia coli. Mfd displaces E. coli RNA polymerase (Pol) stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription. Here, the interactions of Mfd (transcription-repair coupling factor, TRCF) with DNA, RNA Pol, and UvrA were investigated. TRCF bound...
Topics
- Adenosine Triphosphatases
- Bacterial Proteins
- DNA-Binding Proteins
- DNA-Directed RNA Polymerases
- Escherichia coli
- Escherichia coli Proteins
- Mutation
- Nucleic Acids
- Protein Binding
- Structure-Activity Relationship
- Transcription Factors