Article
Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair: in vitro complementation with purified coupling factor.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991
Selby C P, Witkin E M, Sancar A
Abstract excerpt
Mutation frequency decline (MFD) is the rapid decrease in the frequency of certain induced nonsense suppressor mutations occurring when protein synthesis is transiently inhibited immediately after irradiation. MFD is abolished by mutations in the uvrA, -B, or -C genes, which prevent excision repair, or by a mfd mutation, which reduces the rate of excision but does not affect survival. Using an in vitro repair...
Topics
- Alleles
- Bacterial Proteins
- Cell-Free System
- DNA Repair
- Escherichia coli
- Genes, Bacterial
- Genes, Suppressor
- Genetic Complementation Test
- Mutagenesis
- Mutation
- Phenotype