Article
Development of a quasispecies of human immunodeficiency virus type 1 in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1992
Cichutek K, Merget H, Norley S, Linde R, Kreuz W, Gahr M, Kurth R
Abstract excerpt
During treatment with one specific batch of blood clotting factor IX, a number of hemophilia B patients in Germany recently became infected with human immunodeficiency virus type 1 (HIV-1). The nucleotide sequences of cloned HIV-1 envelope gene regions including the variable V3 loop and the V4 region derived from short-term virus cultures and directly from peripheral blood cells of these patients were shown to be...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Cloning, Molecular
- DNA, Viral
- Drug Contamination
- Factor IX
- Genetic Variation
- Genotype
- HIV-1
- Hemophilia A